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pentobarbital will decrease the extent or outcome of bexarotene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will minimize the level or outcome of ethotoin by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.benzhydrocodone/acetaminophen and pentobarbital each enhance sedation.